While CD20 has a higher average density of surface molecules per tumor cell, CD19 expression is more homogenous and is preserved in small CD20-negative tumor subsets and after anti-CD20 targeted …
2019 Oct 30;3(6):e308.
Aims:
Cortelazzo S, Ponzoni M, Ferreri AJ, Hoelzer D. Crit Rev Oncol Hematol. Rust BJ, Kean LS, Colonna L, Brandenstein KE, Poole NH, Obenza W, Enstrom MR, Maldini CR, Ellis GI, Fennessey CM, Huang ML, Keele BF, Jerome KR, Riley JL, Kiem HP, Peterson CW.
| The results showed that the positive rate of CD19 (115/116, 99.1%) in 116 cases with B lineage acute lymphoblastic leukemia (B lineage ALL) was significantly higher than that of CD20 (33/116, 28.4%) (P < 0.01); in 17 patients with B lineage/Myeloid (B/My) acute mixed lineage leukemia (AMLL), the former positive rate (17/17, 100%) was also higher than the latter (5/17, 29.4%) (P < 0.01). When compared with background benign B-cells, CD20 was frequently overexpressed on tumor cells (mean MFR=1.8), while CD19 expression was overall similar to background benign B-cells (mean MFR=0.9) (p=0.001). The results identified distinct profiles of CD19 and CD20 expression in the various types of B cell leukaemias.
Standard microbeads with different capacities to bind mouse immunoglobulins were used to convert the mean fluorescence intensity (MFI) values into number of antigen molecules/cell, expressed as antibody binding capacity (ABC). [CD43 in B-cell chronic lymphocytic leukemia].
Search for other works by this author on: © 2019 by The American Society of Hematology, Copyright ©2020 by American Society of Hematology, 627.Aggressive Lymphoma (Diffuse Large B-Cell and Other Aggressive B-Cell Non-Hodgkin Lymphomas)-Results from Retrospective/Observational Studies, https://doi.org/10.1182/blood-2019-129600. National Center for Biotechnology Information, Unable to load your collection due to an error, Unable to load your delegates due to an error. 2020 Mar 24:10.1038/s41375-020-0792-2. Please enable it to take advantage of the complete set of features! Methods: Flow cytometric analysis (seven-color) was performed on biopsy specimens from 47 patients with newly diagnosed B-cell lymphomas, including diffuse large B-cell lymphoma (n=15), follicular lymphoma (n=15), marginal zone lymphoma (n=9), mantle cell lymphoma (n=9), Burkitt lymphoma (n=2), and unclassifiable low-grade B-cell lymphoma (n=2).
2012;2012:645-51. doi: 10.1182/asheducation-2012.1.645. USA.gov. While CD20 has a higher average density of surface molecules per tumor cell, CD19 expression is more homogenous and is preserved in small CD20-negative tumor subsets and after anti-CD20 targeted therapy. 2011 Sep;79(3):330-43. doi: 10.1016/j.critrevonc.2010.12.003. NIH The specificity of CD19 and CD20 in B lymphocytic lineage was 92.3% (132/143) and 92.7% (38/41), respectively, while the sensitivity was 99.2% (132/133) and 28.6% (38/133), respectively, the former sensitivity was significantly higher than the latter (chi(2) = 144.018, P = 0.001). 1999 Sep;102(3):753-62. NLM CD19 and CD20 ABC values in leukaemic B cells differed from those of normal blood B lymphocytes.
B- and T-cell prolymphocytic leukemia: antibody approaches.
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Pedro Horna, Grzegorz Nowakowski, Jan Endell, Rainer Boxhammer; Comparative Assessment of Surface CD19 and CD20 Expression on B-Cell Lymphomas from Clinical Biopsies: Implications for Targeted Therapies. Of eight additional cases studied post-anti-CD20 immunotherapy (6-84 months after last dose), the percentage of antigen-positive events by tumor cells was largely preserved for both CD19 (median=99.6%, range=93.5-100%) and CD20 (median=95.7%, range=55.6-100%), similar to the pre-therapy cohort. It is concluded that CD19 continuously and steadily express on almost all subtypes of B lineage leukemic cells with homogeneous pattern while only a small number of leukemias express CD20. Chen YH, Tang YM, Shen HQ, Song H, Yang SL, Shi SW, Qian BQ, Xu WQ, Ning BT. 2020 Apr;59(4):463-474. doi: 10.1007/s40262-019-00823-8. These findings support the clinical evaluation of anti-CD19 immunotherapies and combinational therapies targeting both surface antigens. Asterisk with author names denotes non-ASH members.
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